María Granillo boasts an extensive catalog of musical works that encompass all formats, from chamber and vocal music to mixed ensembles, symphonic music, opera, as well as original music for theater, film, and dance.

Her music has been commissioned and performed by the most prominent soloists and ensembles in Mexico's contemporary music scene, as well as by the country's leading orchestras, including OFUNAM, OFCM, OSN, OCBA, OSEM, OFEQ, OA, OFJ, and OSUANL.

Her work is characterized by the use of an eclectic, lyrical, and expressive language that conveys a wide range of emotions.

Her musical poetry, often inspired by natural phenomena and world mythologies, seeks the dynamic integration of technical and aesthetic aspects in each piece.